LDH (Lactate Dehydrogenase)
Definition
LDH is an enzyme that helps cells produce energy and is found in nearly all tissues of the body; it is most concentrated in muscle, liver, kidney, and red blood cells. When tissue is damaged, cells release LDH into the blood or other body fluids.
Purpose
Primarily used to investigate tissue damage. It is used in the diagnosis and monitoring of blood disorders (including anemia), liver, kidney, lung, and heart disease, brain and spinal cord conditions, pancreatic disease, certain cancers (lymphoma, leukemia, melanoma, myeloma), severe infections, and progressive conditions such as muscular dystrophy and HIV. It can also be used to monitor whether cancer treatment is working.
Results
High levels generally point to some form of tissue damage caused by disease, infection, or injury. Low levels are rare and are usually not significant.
Risks and Limitations
LDH cannot show where the damage is or its cause. For this reason it is ordered together with other tests rather than on its own.
Intense exercise and certain medications, including aspirin, can raise LDH.