Definition

In this approach, separate STR profiles are obtained for both the donor and the recipient before transplantation, and distinguishing loci are identified; after transplantation, the allele ratios at these loci in the sample are compared to calculate donor and recipient cell percentages. The two-sample approach provides a more reliable baseline comparison than single-sample analysis.

Method

DNA analysis

Accepted sample types

Blood (EDTA) and Swab

Description

Post-transplant transplantation success.

Inheritance

Individuals' inherited STR polymorphisms are used; the test itself is not a mutation analysis but a tissue-origin determination test (donor vs. recipient).

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Inheritance Patterns

Describes how a genetic condition is passed on within a family. There are five main patterns

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Carrier (Heterozygous / Homozygous)

Why it matters: In autosomal recessive inheritance, when each parent is a carrier (while both appear healthy), the chance of their child being born with the disease is 25% in each

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VUS (Variant of Uncertain Significance)

This is the situation where the test has detected a change in the DNA, but the role of this change in the development of disease is unconfirmed.

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How to Read a Genetic Test Result (Positive / Negative / VUS)

A genetic test result falls into three main categories

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Types of Genetic Tests

A genetic test is a type of medical test that detects changes in genes, chromosomes or proteins. Today there are more than 77,000 genetic tests available.

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