Definition

The MET (c-MET) gene encodes the hepatocyte growth factor receptor. MET amplification is one of the most important mechanisms of acquired resistance to first/second generation EGFR-TKI treatment in EGFR-mutant NSCLC patients and is detected in approximately 5 to 22% of patients who develop resistance; it is also increasingly recognized as a resistance mechanism to third generation TKIs (osimertinib).

Method

FISH analysis

Accepted sample types

Fresh tumor tissue, FFPE

Description

Prognosis.

Inheritance

MET amplification is an acquired (somatic) resistance mechanism that develops in the tumor during EGFR-TKI treatment; it is not a hereditary variant.

Related Tests

Inheritance Patterns

Describes how a genetic condition is passed on within a family. There are five main patterns

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Carrier (Heterozygous / Homozygous)

Why it matters: In autosomal recessive inheritance, when each parent is a carrier (while both appear healthy), the chance of their child being born with the disease is 25% in each

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VUS (Variant of Uncertain Significance)

This is the situation where the test has detected a change in the DNA, but the role of this change in the development of disease is unconfirmed.

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How to Read a Genetic Test Result (Positive / Negative / VUS)

A genetic test result falls into three main categories

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Types of Genetic Tests

A genetic test is a type of medical test that detects changes in genes, chromosomes or proteins. Today there are more than 77,000 genetic tests available.

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