Preimplantation genetic testing (PGT) is the genetic examination of a few cells taken from embryos obtained during assisted reproduction (IVF). The aim is to help identify the most suitable embryo for transfer.
Types of PGT
- PGT-A, screening for chromosome number abnormalities (aneuploidy)
- PGT-M, examination of embryos for a known single-gene disease in the family
- PGT-SR, when one of the parents carries a structural chromosome rearrangement (translocation, etc.)
Who can it be considered for?
PGT may be considered for couples with recurrent pregnancy loss, recurrent implantation failure, advanced maternal age, a family history of single-gene disease or known balanced translocation carrier status. The decision is made together with a reproductive medicine specialist and a genetic counselor, taking the couple's history and expectations into account.
PGT is a screening and examination method; it does not guarantee pregnancy in every case, and prenatal diagnostic tests may still be recommended once pregnancy is achieved.
