Definition

This RNA-based NGS panel screens, in a single run, clinically actionable gene fusions in solid tumors across 25 genes (including ALK, ROS1, RET, NTRK1/2/3, FGFR1-3 and MET). These fusions determine response to tyrosine kinase inhibitor therapy, particularly in NSCLC, thyroid cancer and sarcomas; the RNA-based approach can also capture intronic breakpoints that DNA panels may miss.

Gene/region examined

NOTCH2, NTRK1, ALK, FGFR3, PDGFRA, TERT, PDGFRB, ROS1, MYB, ETV1, EGFR, MET, BRAF, NRG1, NTRK2, RET, FGFR2, ETV6, NUTM1, NTRK3, ETV4, BRD4, ERG, EWSR1, TFE3

Method

Next Generation Sequencing

Accepted sample types

Solid Tumor, FFPE

Inheritance

Detects acquired somatic gene fusions in tumor tissue that arise from chromosomal rearrangements.

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Carrier (Heterozygous / Homozygous)

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VUS (Variant of Uncertain Significance)

This is the situation where the test has detected a change in the DNA, but the role of this change in the development of disease is unconfirmed.

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How to Read a Genetic Test Result (Positive / Negative / VUS)

A genetic test result falls into three main categories

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A genetic test is a type of medical test that detects changes in genes, chromosomes or proteins. Today there are more than 77,000 genetic tests available.

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