BioER and MicroVE are advanced tests designed to optimize implantation success rates by assessing endometrial receptivity. BioER analyzes the transcriptional activity of key genes to identify the window of implantation (WOI), when the endometrium is most receptive to an embryo. MicroVE evaluates the endometrial microbiota and identifies microbial imbalances that may affect implantation. Together, these tests offer a comprehensive approach to improving fertility outcomes.
BioER: Endometrial Receptivity Test
Endometrial receptivity tests aim to increase the chance of a successful pregnancy by determining the optimal time for embryo transfer during IVF. The window of implantation (WOI), the critical period when the endometrial lining of the uterus is most receptive to an embryo, usually occurs 6 to 10 days after ovulation but can vary between individuals.
The exact timing of the WOI is determined by analyzing the gene expression profiles of the endometrium. Test results may show that the endometrium is pre-receptive (too early for implantation), receptive (the optimal time for embryo transfer) or post-receptive (too late for implantation):
- Pre-receptive: If the endometrium is not yet receptive, embryo transfer can be postponed to align with the WOI.
- Receptive: If the endometrium is receptive, the transfer can proceed and the chance of successful implantation is maximized.
- Post-receptive: If the window has passed, transfer timing can be adjusted in future cycles to match the WOI.
MicroVE: Endometrial Microbiota Test
The MicroVE test is a specialized diagnostic tool that analyzes the endometrial microbiota, focusing in particular on the presence and balance of bacterial species such as Lactobacillus. A healthy endometrium is usually dominated by Lactobacillus species, which create an acidic environment that forms a protective barrier against harmful pathogens. When the microbiota balance is disrupted, bacterial vaginosis or other dysbiotic conditions can develop, creating a less favorable environment for embryo implantation.
- High Lactobacillus dominance: Indicates a healthy microbiome and an optimal environment for embryo implantation and pregnancy.
- Low Lactobacillus levels: Indicates a dysbiotic state; the balance may need to be restored with probiotic treatment or antibiotics before embryo transfer.
- Presence of pathogenic bacteria: Indicates the need for targeted antimicrobial treatment to eliminate harmful bacteria and increase the chance of a successful pregnancy.
Understanding the specific microbial environment of the endometrium allows personalized interventions and increases the success rates of IVF treatments by optimizing the conditions for embryo implantation.