The Y chromosome microdeletion test is used to identify the underlying causes of male infertility. There is a strong association between microdeletions on the Y chromosome and infertility. For example, microdeletions in the AZF regions are found in about 15% of non-obstructive azoospermia cases and 5 to 10% of severe oligospermia cases.
The AZF regions are located on the long arm of the Y chromosome and contain vital genes involved in sperm production. Deletions in these regions can affect fertility by causing varying degrees of impairment in sperm production.
Information about these microdeletions makes a valuable contribution to determining appropriate treatment strategies.